The only thing to do is to recompile your application to be 64-bit, no need to change any code. New DYMO Label Framework API. Starting this introduces a new API – the DYMO Label Framework. It provides a simpler streamlined interface for printing labels. Major Features. Support for 32-bit and 64-bit applications. Support for Tape printers. DYMO Label Software Application Version 5.0.5 for Mac OS 8.6 to Mac OS 9.x ONLY Software and drivers for the LabelWriter XL, EL, and 300 series running Mac OS 8.6 through 9.x (NOTE: Mac OS 8.5 and earlier are no longer supported). Shop DYMO label makers, label printers and labels. DYMO offers easy-to-use labelers, LabelWriter printers, plus Rhino industrial labeling products.
DYMO LabelWriter Software v8.5.2 for Mac OS X
Below is the latest version of the Dymo Label Software and Drivers, suitable for the new Yosemite upgrade.
Full labelling capability, including printing barcodes and printing from address lists. Now includes printing wirelessly to the LabelManager Wireless PnP label printer. Compatible with all DYMO PC-connected LabelWriter and LabelManager label printers.
Dymo Label Software Mac
Supports Mac OS X 10.10 ('Yosemite')
Update 05-SEP-2015: Also appears to work with 'El Capitan' (public beta)
NEW: DOWNLOAD 8.5.4 (Sierra) HERE
If you have any problems with this new driver from Dymo, please contact Dymo technical support - helpdesk@dymo.com
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DYMO LabelWriter Software v8.5.4 for Mac OS X
Below is the latest version of the Dymo Label Software and Drivers for Mac OS 10.12 Sierra.
Full labelling capability, including printing barcodes and printing from address lists. Now includes printing wirelessly to the LabelManager Wireless PnP label printer. Compatible with all DYMO PC-connected LabelWriter and LabelManager label printers.

Supports:

Dymo Label Software 64 Bit
- Mac OS X 10.10 ('Yosemite')
- Mac OS X 10.11 ('El Capitan')
- Mac OS X 10.12 ('Sierra')
New: